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――――――DSB repair pathway choice――――――

HR initiation at transcription active loci Yasuhara et al., Cell, 2018

DSB repair pathway choice in G1 Biehs et al., Mol Cell, 2017

53BP1 dephosphorylation promotes pro-HR environment Isono et al., Cell Rep, 2017

MRE11-dependent initiation of resection Shibata et al., Mol Cell, 2014

DSB repair pathway choice in G2 Shibata et al., EMBO J, 2011

―――DDR dependent immune ligands regulation―――

BER deficiency upregulates PD-L1 expression Permata et al., Oncogene, 2019

DSB-dependent ATR/Chk1 upregulats PD-L1 expression Sato et al., Nat Comm, 2017


Google Scholar Profile (Atsushi Shibata)


Please contact me if you are interested in working with us as a JSPS postdoctoral fellow!

https://www.jsps.go.jp/english/e-fellow/

https://www.jsps.go.jp/english/e-inv/



~2020~

Atsushi Shibata and Penny A Jeggo.
Canonical DNA non-homologous end-joining; capacity versus fidelity.
The British Institute of Radiology, 10.1259, 20190966, 2020.


~2019~

・Maxim Shevtsov, Gabriele Multhoff, Elena Mikhaylova, Atsushi Shibata, Irina Guzhova and Boris Margulis.
Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors.
International Journal of Molecular Sciences, 20(21), 5284, 2019.

Sangeeta Kakoti, Motohiro Yamauchi, Wenchao Gu, Reona Kato, Takaaki Yasuhara, Yoshihiko Hagiwara, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
p53 deficiency augments nucleolus instability after ionizing irradiation.
Oncology Reports, 42(6):2293-2302, 2019
*Corresponding author


・Hiro Sato, Penny A. Jeggo and  Atsushi Shibata*.
Regulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicine.
Cancer Science, 110(11):3415-3423,2019
*Corresponding author


・Narisa Dewi Maulany Darwis, Ankita Nachankar, Yasushi Sasaki, Toshiaki Matsui, Shin-ei Noda, Kazutoshi Murata, Tomoaki Tamaki, Ken Ando, Noriyuki Okonogi, Shintaro Shiba, Daisuke Irie, Takuya Kaminuma, Takuya Kumazawa, Mai Anakura, Souichi Yamashita, Takashi Hirakawa, Sangeeta Kakoti, Yuka Hirota, Takashi Tokino, Akira Iwase, Tatsuya Ohno, Atsushi Shibata, Takahiro Oike and Takashi Nakano.
FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy.
International Journal of Molecular Sciences20(18), 4563, 2019.

・Toshiaki Matsui, Endang Nuryadi, Shuichiro Komatsu, Yuka Hirota, Atsushi Shibata, Takahiro Oike and Takashi Nakano.
Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity.
International Journal of Molecular Sciences, 20(17), 4148, 2019.

・Shuichiro Komatsu, Takahiro Oike, Yuka Komatsu, Yoshiki Kubota, Makoto Sakai, Toshiaki Matsui, Endang Nuryadi, Tiara Bunga Mayang Permata, Hiro Sato, Hidemasa Kawamura, Masahiko Okamoto, Takuya Kaminuma, Kazutoshi Murata, Naoko Okano, Yuka Hirota, Tatsuya Ohno, Jun-ichi Saitoh, Atsushi Shibata and Takashi Nakano .
Deep learning-assisted literature mining for in vitro radiosensitivity data.
Radiotherapy & Oncology, Volume 139, Pages 87–93, 2019.

・Mai Anakura, Ankita Nachankar, Daijiro Kobayashi, Napapat Amornwichet, Yuka Hirota, Atsushi Shibata, Takahiro Oike and Takashi Nakano.
Radiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses.
International Journal of Molecular Sciences20(15), 3635, 2019.


Atsushi Shibata, Takaaki Yasuhara.
Elucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.
Impact, Volume 2019, Number 3, pp. 50-51(2), 2019.

・Maxim Shevtsov*, Hiro Sato, Gabriele Multhoff and Atsushi Shibata*.
Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.
Frontiers in Oncology, 9(156): eCollection, 2019.
*Corresponding author

・Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Hiro Sato, Takaaki Yasuhara, Takahiro Oike, Soehartati Gondhowiardjo, Kathryn D. Held, Takashi Nakano & Atsushi Shibata*.
Base excision repair regulates PD-L1 expression in cancer cells.
Oncogene, 10.1038/s41388-019-0733-6, 2019.
*Corresponding author

Atsushi Shibata and Penny Jeggo*
A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present.
International Journal of Radiation Biology , 10.1080/09553002, 2019.
*Corresponding author

Yoshihiko Hagiwara#, Takahiro Oike#, Atsuko Niimi#, Motohiro Yamauchi, Hiro Sato, Siripan Limsirichaikul, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation.
Journal of Radiation Research, 60(1):69-79 , 2019.
*Corresponding author


~2018~

Takaaki Yasuhara#*, Reona Kato#, Yoshihiko Hagiwara, Bunsyo Shiotani, Motohiro Yamauchi, Shinichiro Nakada, Atsushi Shibata* and  Kiyoshi Miyagawa*.
Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.
Cell, 175 (2):558-570, 2018. (citation 7:  2019)
*Co-corresponding author

Atsushi Shibata
, Penny Jeggo and Markus Lobrich.
The pendulum of the Ku-Ku clock.
DNA repair, 71:164-171, 2018.

Endang Nuryadi#, Yasushi Sasaki#, Yoshihiko Hagiwara# et al., Atsushi Shibata, Tatsuya Ohno, Takashi Tokino, Takahiro Oike and Takashi Nakano.
Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.
Oncotarget, 9:32642-32652, 2018.

Yoshihiko Hagiwara, Hiro Sato, Tiara Bunga Mayang Permata, Atsuko Niimi, Motohiro Yamauchi, Takahiro Oike, Takashi Nakano and Atsushi Shibata*.
Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage.
Human Immunology, 79(8):627-631, 2018.
 *Corresponding author

 

~2017~

Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano and Atsushi Shibata*.
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
Nature Communications, 8(1):1751, 2017. (citation 35:  2019)
*Corresponding author

Yoshihiko Hagiwara, Atsuko Niimi, Mayu Isono, Motohiro Yamauchi, Takaaki Yasuhara, Siripan Limsirichaikul, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.
Oncotarget, 8:109370-109381, 2017.
*Corresponding author

Ryo Sakasai, Mayu Isono, Mitsuo Wakasugi, Mitsumasa Hashimoto, Yumi Sunatani, Tadashi Matsui, Atsushi Shibata, Tsukasa Matsunaga & Kuniyoshi Iwabuchi .
Aquarius is required for proper CtIP expression and homologous recombination repair.
Scientific Reports, 7:13808, 2017.

Atsushi Shibata*.
Regulation of repair pathway choice at two-ended DNA double-strand breaks.
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,
803-805:51-55, 2017.
*Corresponding author

Nakako Izumi Nakajima, Atsuko Niimi, Mayu Isono, Takahiro Oike, Hiro Sato, Takashi Nakano, and Atsushi Shibata*.
Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.
Oncology Reports, 38: 693-702, 2017. 
*Corresponding author

Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano and Atsushi Shibata*.
BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation.
Cell Reports, 18(2):520-532, 2017. (citation 32:  2019)
*Corresponding author


Ronja Biehs, Monika Steinlage, Olivia Barton, Szilvia Juhasz, Julia Kunzel, Julian Spies, Atsushi Shibata*, Penny Jeggo* and Markus Lobrich*.
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.
Molecular Cell,S1097-2765(16)30854-1, 2017. (citation 65:  2019)
*Co-corresponding authors


Motohiro Yamauchi, Atsushi Shibata, Keiji Suzuki, Masatoshi Suzuki, Atsuko Niimi, Hisayoshi Kondo, Miwa Miura, Miyako Hirakawa, Keiko Tsujita, Shunichi Yamashita, Naoki Matsuda.
Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1.
Scientific Reports, 7:41812, 2017.


Daijiro Kobayashi, Takahiro Oike, Atsushi Shibata, Atsuko Niimi, Yoshiki Kubota, Makoto Sakai, Napapat Amornwhichet, Yuya Yoshimoto, Yoshihiko Hagiwara, Yuka Kimura, Yuka Hirota, Hiro Sato, Mayu Isono, Yukari Yoshida, Takashi Kohno, Tatsuya Ohno and Takashi Nakano.
Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon and cisplatin.
Scientific Reports, 7:40588, 2017.

~2016~
Atsuko Niimi, Motohiro Yamauchi, Siripan Limsirichaikul, Ryota Sekine, Takahiro Oike, Hiro Sato, Keiji Suzuki, Kathryn D. Held, Takashi Nakano, and Atsushi Shibata*.
Identification of DNA Double Strand Breaks at Chromosome Boundaries Along the Track of Particle Irradiation.
Genes, Chromosomes and Cancer,55(8):650-60, 2016.
*Corresponding author


Takahiro Oike, Atsuko Niimi, Noriyuki Okonogi, Kazutoshi Murata, Akihiko Matsumura, Shin-Ei Noda, Daijiro Kobayashi, Mototaro Iwanaga, Keisuke Tsuchida, Tatsuaki Kanai, Tatsuya Ohno, Atsushi Shibata* & Takashi Nakano*
Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.
Scientific Reports, 6:22275, 2016.
*Corresponding author


Laura A. Tookman, Ashley K. Browne, Claire M. Connell, Gemma Bridge, Carin K. Ingemarsdotter, Suzanne Dowson, Atsushi Shibata, Michelle Lockley, Sarah A. Martin, and Iain A. McNeish.
RAD51 and BRCA2 promote oncolytic adenovirus type 5 activity in ovarian cancer. 
Molecular Cancer Research, 14(1):44-55, 2016.

~2015~
Meryem Alagoz, Yoko Katsuki, Hideaki Ogiwara, Tomoo Ogi, Atsushi Shibata, Andreas Kakarougkas, and Penny Jeggo. 
SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells.
Nucleic Acids Research, 43(16):7931-44, 2015.


Naoyuki Okita and Atsushi Shibata*.
Other Determinants of Sensitivity (Chapter 15). 
PARP Inhibitors for Cancer Therapy, Cancer Drug Discovery and Development 83, 2015
*Corresponding author


Napapat Amornwichet, Takahiro Oike, Atsushi Shibata, Chaitanya S. Nirodi, Hideaki Ogiwara, Haruhiko Makino, Yuka Kimura, Yuka Hirota, Mayu Isono, Yukari Yoshida, Tatsuya Ohno, Takashi Kohno & Takashi Nakano. 
The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells. 
Scientific Reports, srep11305, 
2015 Jun 11.


Mayu Isono, Yukari Yoshida, Akihisa Takahashi, Takahiro Oike, Atsushi Shibata, Yoshiki Kubota, Tatsuaki Kanai, Tatsuya Ohno, and Takashi Nakano. 
Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.
Journal of Radiation Research, 56(5):856-61, 2015.

Nakako Izumi Nakajima#, Yoshihiko Hagiwara#, Takahiro Oike, Ryuichi Okayasu, Takeshi Murakami, Takashi Nakano, and Atsushi Shibata*. 
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
PLOS ONE, 10(3):e0122582, 2015.
#Equal first author. *Corresponding author

~2014~
Atsushi Shibata, Penny Jeggo. 
DNA double-strand break repair in a cellular context.
Clinical Oncology(R Coll Radiol), 26(5):243-9, 2014.

Napapat Amornwichet, Takahiro Oike , Atsushi Shibata, Hideaki Ogiwara, Naoto Tsuchiya, Motohiro Yamauchi, Yuka Saitoh, Ryota Sekine, Mayu Isono, Yukari Yoshida,  Tatsuya Ohno, Takashi Kohno, Takashi Nakano.
Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe.
PLOS ONE,  9(12):e115121, 2014.


Atsushi Shibata, Davide Moiani, Andrew S. Arvai, Jefferson Perry, Shane M. Harding, Marie-Michelle Genois, Ranjan Maity, Sari van Rossum-Fikkert, Aryandi Kertokalio, Filippo Romoli, Amani Ismail, Ermal Ismalaj, Elena Petricci, Matthew J. Neale, Robert G. Bristow, Jean-Yves Masson, Claire Wyman, Penny A. Jeggo, John A. Tainer. 
DNA Double Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. 
Molecular Cell, 53 (1), 7-18, 2014.(citation 260:  2019)

~2013~
Nakako Izumi Nakajima, Holly Brunton, Ritsuko Watanabe, Amruta Shrikhande, Ryoichi Hirayama,  Naruhiro Matsufuji, Akira Fujimori, Takeshi Murakami, Ryuichi Okayasu, Penny Jeggo and Atsushi Shibata*.
Visualisation of gH2AX foci caused by heavy ion particle traversal; Distinction between core track versus non-track damage.
PLOS ONE, 14;8(8):e70107, 2013.
*corresponding author

Andreas Kakarougkas, Amani Ismail, Yoko Katsuki, Raimundo Freire, Atsushi Shibata and Penny Jeggo.
Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.
Nucleic Acids Research, 41(22):10298-311, 2013.

Andreas Kakarougkas, Amani Ismail, Karolin Klement, Aaron Goodarzi, Sandro Conrad, Raimundo Freire, Atsushi Shibata, Markus Löbrich and Penny Jeggo.
Opposing roles for 53BP1 during homologous recombination.
Nucleic Acids Research, 41(21), 9719-9731, 2013.

~2011~
Holly Brunton, Aaron A. Goodarzi, Angela T. Noon, R. Scott Hansen, Penny A. Jeggo and Atsushi Shibata*
Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.
Molecular and Cellular Biology, 31(19):4022-4035, 2011.
*corresponding author

Lisa Woodbine, Holly Brunton, Aaron A. Goodarzi, Atsushi Shibata, and Penny A. Jeggo.
Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.
Nucleic Acids Research, 39(16):6986-6997, 2011.

Atsushi Shibata, Sandro Conrad, Julie Birraux, Verena Geuting, Olivia Barton, Amani Ismail, Andreas Kakarougkas, Katheryn Meek, Gisela Taucher-Scholz, Markus Löbrich and Penny A Jeggo.
Factors determining DNA double-strand break repair pathway choice in G2 phase.
EMBO J, 30(6):1079-92, 2011.(citation 340:  2019)

Claire M. Connell*, Atsushi Shibata*, Laura A. Tookman, Kyra Archibald, Magdalena B. Flak, Katrina J. Pirlo, Michelle Lockley, Sally P. Wheatley, Iain A. McNeish.
Genomic DNA damage and ATR-Chk1 signalling determine oncolytic adenoviral efficacy in human ovarian cancer.
Journal of Clinical Investigation, 121(4):1283-97, 2011.
*These authors contributed equally to this work.

~2010~
Dana A. Löser*,Atsushi Shibata*, Akiko K. Shibata, Lisa J. Woodbine, Penny A. Jeggo and Anthony J. Chalmer.
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.
Molecular Cancer Therapeutics, 9 (6),1775-87, 2010.
*These authors contributed equally to this work.(citation 113:  2019)

Atsushi Shibata, Olivia Barton, Angela T. Noon, Kirsten Dahm, Dorothee Deckbar,Aaron A. Goodarzi, Markus Löbrich, and Penny A. Jeggo.
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G2/M checkpoint arrest.
Molecular and Cellular Biology, 30 (13), 3371–3383, 2010.(citation 112:  2019)

Angela T. Noon, Atsushi Shibata, Nicole Rief, Markus Löbrich, Grant S. Stewart, Penny A. Jeggo and Aaron A. Goodarzi.
53BP1-dependent robust localized KAP‑1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
Nature Cell Biology, 12 (2), 177-184, 2010.(citation 286:  2019)

Markus Löbrich, Atsushi Shibata, Andrea Beucher, Anna Fisher, Michael Ensminger, Aaron A. Goodarzi, Olivia Barton and Penny A. Jeggo.
gH2AX foci analysis for monitoring DNA double-strand break repair – Strengths, limitations and optimization.
Cell Cycle, 9 (4), 662-669, 2010.(citation 507:  2019)

~2009~
Andrea Beucher, Julie Birraux, Leopoldine Tchouandong, Olivia Barton, Atsushi Shibata, Sandro Conrad, Aaron A Goodarzi, Andrea Krempler, Penny A Jeggo, and Markus Löbrich.
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.
EMBO J, 28, 3413-3427, 2009.(citation 382:  2019)

Atsushi Shibata, Olivia Barton, Angela T. Noon, Dorothee Deckbar, Aaron A. Goodarzi, Markus Löbrich and Penny A. Jeggo.
The maintenance of ATM dependent G2/M checkpoint arrest following exposure to ionizing radiation.
Acta Med. Nagasaki, Vol. 53, 19-21, 2009

Atsushi Shibata, Daisuke Maeda, Hideki Ogino, Masahiro Tsustsumi, Takehiko Nohmi, Hitoshi Nakagama, Takashi Sugimura, Hirobumi Teraoka and Mitsuko Masutani.
Role of Parp-1 in suppressing spontaneous deletion mutation at non-repeat or short repeat of mononucleotide sequences in the mouse liver in the process of aging.
Mutation Research –Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 664, 20-27, 2009.

~2006~
Ryo Sakasai, Keitaro Shinohe, Yosuke Ichijima, Naoyuki Okita, Atsushi Shibata, Kinji Asahina and Hirobumi Teraoka.
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.
Genes to Cells, Vol. 11, 237-246, 2006.

Hideki Ogino, Atsushi Shibata, Akemi Gunji, Hiroshi Suzuki, Hitoshi Nakagama, Takashi Sugimura, Mitsuko Masutani.
Agent-dependent effects of Parp-1 deficiency on DNA damage responses and genomic stability in mouse ES cells. In: Grier EV (ed), New Developments in Stem Cell Research, Hauppauge, New York, USA.
Nova Science Publishers, Inc, pp 133-147, 2006.

~2005~
Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani.
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.
Oncogene, 24, 1328-1337, 2005.

~2004~
Atsushi Shibata, Mitsuko Masutani, Nobuo Kamada, Ken-ichi Masumura, Hitoshi Nakagama, Shizuko Kobayashi, Hirobumi Teraoka, Hiroshi Suzuki and Takehiko Nohmi.
Efficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes.
Environmental and Molecular Mutagenesis, 43, 204-207, 2004.

~2003~
Atsushi Shibata, Mitsuko Masutani, Tadashige Nozaki, Nobuo Kamada, Hisako Fujihara, Ken-ichi Masumura, Hitoshi Nakagama, Takashi Sugimura, Shizuko Kobayashi, Hiroshi Suzuki and Takehiko Nohmi.
Improvement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation.
Environmental and Molecular Mutagenesis, 41, 370-372, 2003.

~2002~
Mitsuko Masutani, Takushi Shimokawa, Masayuki Igarashi, Masa Hamada, Atsushi Shibata, Sachiho Oami, Tadashige Nozaki, Hitoshi Nakagama, Takashi Sugimura, Tomio Takeuchi, Makoto Hori.
Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues.
Proceedings of the Japan Academy, Vol. 78, Ser. B, No. 1, 2002.

Grant

1. 2017.4~2021.3  Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists A

2.
2014.4~2017.3  Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists A

3.2014.4~2016.3  Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research

4.2013.4~2014.3  Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up

5.Suntory Foundation 1,000,000 JPY

6.The Sumitomo Foundation 1,300,000 JPY

7.Takeda Science Foundation 5,000,000 JPY

8.
THE MITSUBISHI foundation

9.The Uehara Memorial Foundation 5,000,000 JPY

10.The Yasuda Memorial Foundation 2,000,000 JPY

11.
Daiichi Sankyo Foundation of Life Science 2,000,000 JPY

12.
Takeda Science Foundation 2,000,000 JPY

13.
 The Cell Research Science Foundation 3,000,000 JPY

14. Kowa Life Science Foundation 1,000,000 JPY

15. The Sumitomo Foundation 1,500,000 JPY

16. Takeda Science Foundation 3,000,000 JPY

17. Mochida Memorial Foundation for Medical and Pharmaceutical Research  3,000,000 JPY

18. The Uehara Memorial Foundation  2,000,000 JPY

19. Terumo Life Science Foundation 1,000,000 JPY

20. Astellas Foundation for Research on Metabolic Disorders  2,000,000 JPY

21. Suzuken Memorial Foundation  1,000,000 JPY

22. Takeda Science Foundation 2,000,000 JPY

23. The Great Britain Sasagawa Small Grant 2012-2013: £3000

24.Daiwa Foundation Small Grants 2008: £1500 

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