Home > Publication

Publication

業績(論文、研究費、学会発表の順に並んでいます)

柴田のGoogle Scholarはこちら



~2018~

Yoshihiko Hagiwara, Hiro Sato, Tiara Bunga Mayang Permata, Atsuko Niimi, Motohiro Yamauchi, Takahiro Oike, Takashi Nakano and Atsushi Shibata*.
Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage.
Human Immunology, In Press・
 *Corresponding author


~2017~

Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano and Atsushi Shibata*.
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
Nature Communicaions, 8(1):1751, 2017
*Corresponding author

Yoshihiko Hagiwara, Atsuko Niimi, Mayu Isono, Motohiro Yamauchi, Takaaki Yasuhara, Siripan Limsirichaikul, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*.
3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.
Oncotarget, 8:109370-109381, 2017.
*Corresponding author

Ryo Sakasai, Mayu Isono, Mitsuo Wakasugi, Mitsumasa Hashimoto, Yumi Sunatani, Tadashi Matsui, Atsushi Shibata, Tsukasa Matsunaga & Kuniyoshi Iwabuchi .
Aquarius is required for proper CtIP expression and homologous recombination repair.
Scientific Reports, 7:13808, 2017.

Atsushi Shibata*.
Regulation of repair pathway choice at two-ended DNA double-strand breaks.
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,
803-805:51-55, 2017.
*Corresponding author

Nakako Izumi Nakajima, Atsuko Niimi, Mayu Isono, Takahiro Oike, Hiro Sato, Takashi Nakano, and Atsushi Shibata*.
Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.
Oncology Reports, 38: 693-702, 2017. 
*Corresponding author

Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano and Atsushi Shibata*.
BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation.
Cell Reports, 18(2):520-532, 2017. 
*Corresponding author


Ronja Biehs, Monika Steinlage, Olivia Barton, Szilvia Juhasz, Julia Kunzel, Julian Spies, Atsushi Shibata*, Penny Jeggo* and Markus Lobrich*.
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.
Molecular Cell, S1097-2765(16)30854-1, 2017.
*Co-corresponding authors


Motohiro Yamauchi, Atsushi Shibata, Keiji Suzuki, Masatoshi Suzuki, Atsuko Niimi, Hisayoshi Kondo, Miwa Miura, Miyako Hirakawa, Keiko Tsujita, Shunichi Yamashita, Naoki Matsuda.
Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1.
Scientific Reports, 7:41812, 2017.


Daijiro Kobayashi, Takahiro Oike, Atsushi Shibata, Atsuko Niimi, Yoshiki Kubota, Makoto Sakai, Napapat Amornwhichet, Yuya Yoshimoto, Yoshihiko Hagiwara, Yuka Kimura, Yuka Hirota, Hiro Sato, Mayu Isono, Yukari Yoshida, Takashi Kohno, Tatsuya Ohno and Takashi Nakano.
Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon and cisplatin.
Scientific Reports, 7:40588, 2017.

~2016~
Atsuko Niimi, Motohiro Yamauchi, Siripan Limsirichaikul, Ryota Sekine, Takahiro Oike, Hiro Sato, Keiji Suzuki, Kathryn D. Held, Takashi Nakano, and Atsushi Shibata*.
Identification of DNA Double Strand Breaks at Chromosome Boundaries Along the Track of Particle Irradiation.
Genes, Chromosomes and Cancer, 55(8):650-60, 2016.
*Corresponding author


Takahiro Oike, Atsuko Niimi, Noriyuki Okonogi, Kazutoshi Murata, Akihiko Matsumura, Shin-Ei Noda, Daijiro Kobayashi, Mototaro Iwanaga, Keisuke Tsuchida, Tatsuaki Kanai, Tatsuya Ohno, Atsushi Shibata* & Takashi Nakano*
Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.
Scientific Reports, 6:22275, 2016.
*Corresponding author


Laura A. Tookman, Ashley K. Browne, Claire M. Connell, Gemma Bridge, Carin K. Ingemarsdotter, Suzanne Dowson, Atsushi Shibata, Michelle Lockley, Sarah A. Martin, and Iain A. McNeish. 
RAD51 and BRCA2 promote oncolytic adenovirus type 5 activity in ovarian cancer. 
Molecular Cancer Research, 14(1):44-55, 2016.

~2015~
Meryem Alagoz, Yoko Katsuki, Hideaki Ogiwara, Tomoo Ogi, Atsushi Shibata, Andreas Kakarougkas, and Penny Jeggo. 
SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells. 
Nucleic Acids Research, 43(16):7931-44, 2015.


Naoyuki Okita and Atsushi Shibata*. 
Other Determinants of Sensitivity (Chapter 15). 
PARP Inhibitors for Cancer Therapy, Cancer Drug Discovery and Development 83, 2015
*Corresponding author


Napapat Amornwichet, Takahiro Oike, Atsushi Shibata, Chaitanya S. Nirodi, Hideaki Ogiwara, Haruhiko Makino, Yuka Kimura, Yuka Hirota, Mayu Isono, Yukari Yoshida, Tatsuya Ohno, Takashi Kohno & Takashi Nakano. 
The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells. 
Scientific Reports, srep11305, 
2015 Jun 11.


Mayu Isono, Yukari Yoshida, Akihisa Takahashi, Takahiro Oike, Atsushi Shibata, Yoshiki Kubota, Tatsuaki Kanai, Tatsuya Ohno, and Takashi Nakano. 
Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.
Journal of Radiation Research, 56(5):856-61, 2015.

Nakako Izumi Nakajima#, Yoshihiko Hagiwara#, Takahiro Oike, Ryuichi Okayasu, Takeshi Murakami, Takashi Nakano, and Atsushi Shibata*. 
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
PLOS ONE, 10(3):e0122582, 2015.
#Equal first author. *Corresponding author

~2014~
Atsushi Shibata, Penny Jeggo. 
DNA double-strand break repair in a cellular context.
Clinical Oncology(R Coll Radiol), 26(5):243-9, 2014.

Napapat Amornwichet, Takahiro Oike , Atsushi Shibata, Hideaki Ogiwara, Naoto Tsuchiya, Motohiro Yamauchi, Yuka Saitoh, Ryota Sekine, Mayu Isono, Yukari Yoshida,  Tatsuya Ohno, Takashi Kohno, Takashi Nakano. 
Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe.
PLOS ONE,  9(12):e115121, 2014.


Atsushi Shibata, Davide Moiani, Andrew S. Arvai, Jefferson Perry, Shane M. Harding, Marie-Michelle Genois, Ranjan Maity, Sari van Rossum-Fikkert, Aryandi Kertokalio, Filippo Romoli, Amani Ismail, Ermal Ismalaj, Elena Petricci, Matthew J. Neale, Robert G. Bristow, Jean-Yves Masson, Claire Wyman, Penny A. Jeggo, John A. Tainer. 
DNA Double Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. 
Molecular Cell, 53 (1), 7-18, 2014.(引用回数  145  2017年現在)

~2013~
Nakako Izumi Nakajima, Holly Brunton, Ritsuko Watanabe, Amruta Shrikhande, Ryoichi Hirayama,  Naruhiro Matsufuji, Akira Fujimori, Takeshi Murakami, Ryuichi Okayasu, Penny Jeggo and Atsushi Shibata*.
Visualisation of gH2AX foci caused by heavy ion particle traversal; Distinction between core track versus non-track damage.
PLOS ONE, 14;8(8):e70107, 2013.
*corresponding author

Andreas Kakarougkas, Amani Ismail, Yoko Katsuki, Raimundo Freire, Atsushi Shibata and Penny Jeggo.
Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.
Nucleic Acids Research, 41(22):10298-311, 2013.

Andreas Kakarougkas, Amani Ismail, Karolin Klement, Aaron Goodarzi, Sandro Conrad, Raimundo Freire, Atsushi Shibata, Markus Löbrich and Penny Jeggo.
Opposing roles for 53BP1 during homologous recombination.
Nucleic Acids Research, 41(21), 9719-9731, 2013.


 < 2012年以前 テニュアトラック就任前 >

~2011~
Holly Brunton, Aaron A. Goodarzi, Angela T. Noon, R. Scott Hansen, Penny A. Jeggo and Atsushi Shibata*
Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.
Molecular and Cellular Biology, 31(19):4022-4035, 2011.
*corresponding author

Lisa Woodbine, Holly Brunton, Aaron A. Goodarzi, Atsushi Shibata, and Penny A. Jeggo.
Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.
Nucleic Acids Research, 39(16):6986-6997, 2011.

Atsushi Shibata, Sandro Conrad, Julie Birraux, Verena Geuting, Olivia Barton, Amani Ismail, Andreas Kakarougkas, Katheryn Meek, Gisela Taucher-Scholz, Markus Löbrich and Penny A Jeggo.
Factors determining DNA double-strand break repair pathway choice in G2 phase.
EMBO J, 30(6):1079-92, 2011.(引用回数  246  2017年現在)

Claire M. Connell*, Atsushi Shibata*, Laura A. Tookman, Kyra Archibald, Magdalena B. Flak, Katrina J. Pirlo, Michelle Lockley, Sally P. Wheatley, Iain A. McNeish.
Genomic DNA damage and ATR-Chk1 signalling determine oncolytic adenoviral efficacy in human ovarian cancer.
Journal of Clinical Investigation, 121(4):1283-97, 2011.
*These authors contributed equally to this work.

~2010~
Dana A. Löser*, Atsushi Shibata*, Akiko K. Shibata, Lisa J. Woodbine, Penny A. Jeggo and Anthony J. Chalmer.
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.
Molecular Cancer Therapeutics, 9 (6),1775-87, 2010.
*These authors contributed equally to this work.(引用回数  101  2017年現在)

Atsushi Shibata, Olivia Barton, Angela T. Noon, Kirsten Dahm, Dorothee Deckbar,Aaron A. Goodarzi, Markus Löbrich, and Penny A. Jeggo.
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G2/M checkpoint arrest.
Molecular and Cellular Biology, 30 (13), 3371–3383, 2010.(引用回数  85  2017年現在)

Angela T. Noon, Atsushi Shibata, Nicole Rief, Markus Löbrich, Grant S. Stewart, Penny A. Jeggo and Aaron A. Goodarzi.
53BP1-dependent robust localized KAP‑1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
Nature Cell Biology, 12 (2), 177-184, 2010.(引用回数  242  2017年現在)

Markus Löbrich, Atsushi Shibata, Andrea Beucher, Anna Fisher, Michael Ensminger, Aaron A. Goodarzi, Olivia Barton and Penny A. Jeggo.
gH2AX foci analysis for monitoring DNA double-strand break repair – Strengths, limitations and optimization.
Cell Cycle, 9 (4), 662-669, 2010.(引用回数  387  2017年現在)

~2009~
Andrea Beucher, Julie Birraux, Leopoldine Tchouandong, Olivia Barton, Atsushi Shibata, Sandro Conrad, Aaron A Goodarzi, Andrea Krempler, Penny A Jeggo, and Markus Löbrich.
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.
EMBO J, 28, 3413-3427, 2009.(引用回数  277  2017年現在)

Atsushi Shibata, Olivia Barton, Angela T. Noon, Dorothee Deckbar, Aaron A. Goodarzi, Markus Löbrich and Penny A. Jeggo.
The maintenance of ATM dependent G2/M checkpoint arrest following exposure to ionizing radiation.
Acta Med. Nagasaki, Vol. 53, 19-21, 2009

Atsushi Shibata, Daisuke Maeda, Hideki Ogino, Masahiro Tsustsumi, Takehiko Nohmi, Hitoshi Nakagama, Takashi Sugimura, Hirobumi Teraoka and Mitsuko Masutani.
Role of Parp-1 in suppressing spontaneous deletion mutation at non-repeat or short repeat of mononucleotide sequences in the mouse liver in the process of aging.
Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 664, 20-27, 2009.

~2006~
Ryo Sakasai, Keitaro Shinohe, Yosuke Ichijima, Naoyuki Okita, Atsushi Shibata, Kinji Asahina and Hirobumi Teraoka.
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.
Genes to Cells, Vol. 11, 237-246, 2006.

Hideki Ogino, Atsushi Shibata, Akemi Gunji, Hiroshi Suzuki, Hitoshi Nakagama, Takashi Sugimura, Mitsuko Masutani.
Agent-dependent effects of Parp-1 deficiency on DNA damage responses and genomic stability in mouse ES cells. In: Grier EV (ed), New Developments in Stem Cell Research, Hauppauge, New York, USA.
Nova Science Publishers, Inc, pp 133-147, 2006.

~2005~
Atsushi Shibata, Nobuo Kamada, Ken-ichi Masumura, Takehiko Nohmi, Shizuko Kobayashi, Hirobumi Teraoka, Hitoshi Nakagama, Takashi Sugimura, Hiroshi Suzuki and Mitsuko Masutani.
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.
Oncogene, 24, 1328-1337, 2005.

~2004~
Atsushi Shibata, Mitsuko Masutani, Nobuo Kamada, Ken-ichi Masumura, Hitoshi Nakagama, Shizuko Kobayashi, Hirobumi Teraoka, Hiroshi Suzuki and Takehiko Nohmi.
Efficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes.
Environmental and Molecular Mutagenesis, 43, 204-207, 2004.

~2003~
Atsushi Shibata, Mitsuko Masutani, Tadashige Nozaki, Nobuo Kamada, Hisako Fujihara, Ken-ichi Masumura, Hitoshi Nakagama, Takashi Sugimura, Shizuko Kobayashi, Hiroshi Suzuki and Takehiko Nohmi.
Improvement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation.
Environmental and Molecular Mutagenesis, 41, 370-372, 2003.

~2002~
Mitsuko Masutani, Takushi Shimokawa, Masayuki Igarashi, Masa Hamada, Atsushi Shibata, Sachiho Oami, Tadashige Nozaki, Hitoshi Nakagama, Takashi Sugimura, Tomio Takeuchi, Makoto Hori.
Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues.
Proceedings of the Japan Academy, Vol. 78, Ser. B, No. 1, 2002.

研究費

< 科研費 >
1. 平成29~32年度 科学研究費助成事業・若手研究A 代表
「転写共役型相同組換え修復の開始を導く分子メカニズムの解明」


2.
平成28~31年度 科学研究費助成事業・基盤研究B 分担
「がん重粒子線治療の高度化と治療個別化の為の基礎的・臨床的研究」

3. 
平成26~28年度 科学研究費助成事業・若手研究A 代表
「相同組換え修復開始を導くクロマチン構造変更後のpseudo転写構造形成の解明」

4.
平成26~27年度 科学研究費助成事業(学術研究助成基金助成金)・挑戦的萌芽研究 代表
「部位特異的制限酵素I-PpoIを応用したPCRによる染色体転座検出法の開発」

5. 平成25年度 科学研究費補助金・研究活動スタート支援  代表
「放射線照射後の欠失・転座を導くDNA二本鎖切断修復経路の解析」

< 民間助成金 >
1.公益財団法人 三菱財団 第49回(平成30年度)自然科学研究助成 代表
「G0/G1 静止期におけるDNA 二本鎖切断修復機構の解明」

2.
公益財団法人 上原記念生命科学財団 平成29年度研究助成金 500万円 代表
「ゲノム安定化維持のためのDNA修復経路選択性の研究」


3.
公益財団法人 安田記念医学財団 平成29年度安田記念医学財団 癌研究助成 200万円 代表 
「重粒子線と抗PD-1抗体治療併用時の抗腫瘍効果を導く分子機構」


4.
公益財団法人 第一三共生命科学研究振興財団 平成28年度研究助成 200万円 代表
「免疫チェックポイント活性化に関わるDNA 修復反応機構の解明」

5. 
公益財団法人武田科学振興財団 2016年度 ビジョナリーリサーチ助成(スタート) 200万円 代表
「DNA修復経路操作を可能とする創薬開発に向けた分子標的の探索」


6. 
公益財団法人細胞科学研究財団 平成28年度研究助成 300万円 代表
「重粒子線治療と抗PD-1抗体併用時の抗腫瘍効果の分子機構」

7. 
公益財団法人興和生命科学振興財団 平成27年度研究助成 100万円 代表
「家族性乳がん原因遺伝子BRCA1欠損細胞における抗がん剤耐性獲得機構の解明」

8. 
公益財団法人住友財団  2015年度基礎科学研究助成  150万円 代表
「遺伝性乳がん卵巣がん症候群における薬剤耐性獲得メカニズムの解明」

9. 
公益財団法人武田科学振興財団  医学系研究奨励継続助成  基礎分野 300万円 代表
「MRE 11阻害剤を用いた放射線療法増感方法の開発とその作用機序の解明」

10. 
公益財団法人 持田記念医学薬学振興財団 研究助成金 300万円 代表
「DNA二本鎖切断修復の経路選択決定を構築する分子ネットワークの解明」

11.
上原記念生命科学財団 研究奨励金 200万円 代表
「DNA 二本鎖切断修復経路を決定する修復開始起点の同定」

12. テルモ科学技術振興財団 一般研究開発助成 100万円 代表
「重粒子線照射後のがん治療標的分子NKG2D発現誘導機構の解明」

13. アステラス病態代謝研究会 研究助成金 200万円 代表
「抗腫瘍免疫応答増強へ向けたDNA損傷応答の解析」

14. 鈴木謙三記念医科学応用研究財団 調査研究助成 100万円 代表
「分子モデリングにより開発した新規相同組換修復阻害剤を用いたがん化及び老化メカニズムの解明」

15. 公益財団法人武田科学振興財団、医学系研究奨励、基礎分野 200万円 代表
「MRE11阻害剤を用いた放射線療法増感効果の検討とその作用機序の解析」

16. The Great Britain Sasagawa Small Grant 2012-2013: £3000 放射線医学総合研究所 岡安隆一グループとの共同研究

17. Daiwa Foundation Small Grants 2008: £1500 慶応義塾大学 医学部 中田慎一郎講師との共同研究 (現大阪大学 准教授)

< 他大学との共同利用・共同研究 >
1. 
2017 放射線災害・医科学研究拠点共同利用・共同研究  代表

2.
 2016 放射線災害・医科学研究拠点共同利用・共同研究  代表

3. 2015 東北大学加齢研共同研究 代表

4. 2014 東北大学加齢研共同研究 代表

5. 
2014 長崎大学原爆後障害医療研究所共同利用・共同研究 代表

6.
 2013 長崎大学原爆後障害医療研究所共同利用・共同研究  代表

 

国際学会

● 口頭発表 (内容はこちらをクリック)

 

● ポスター発表 (内容はこちらをクリック)

 

国内学会 ※近年のみを抜粋 (内容はこちらをクリック)